Exploring the effect of italicYiqi Huayu Qingre Formula/italic (益气化瘀清热方) on biochemical indicators in FSGS rats based on ferroptosis

Key Points

• The aim is to observe the effects of Yiqi Huayu Qingre Formula on proteinuria, urinary iron concentration, and biochemical indicators in FSGS rats.
• 63 male SD rats were randomly divided into 7 groups with 9 rats each.
• FSGS models were induced using adriamycin for 4 weeks and treated with varying doses of the formula or other interventions for another 4 weeks.
• Urinary protein quantification, urinary iron concentration, and serum biochemistry were measured at 24 hours.
• At week 4, all treatment groups showed increased urinary protein levels compared to the control group (P<0.05).
• At week 8, the high-dose formula and ferroptosis inhibitor groups significantly improved urinary protein, urinary creatinine, serum creatinine, and urinary iron concentration compared to the model group (P<0.05).
• Other biochemical indicators showed no significant differences (P>0.05).