Antidepressant medication use in patients with type 2 diabetes and depression was associated with increased odds of achieving good glycaemic control (OR 1.95; 95% CI 1.02-3.71).
Cohort (n=1,399)
Does antidepressant medication use improve glycaemic control in patients with co-morbid type 2 diabetes and depression?
In primary care patients with type 2 diabetes and depression, the use of antidepressant medications is associated with significantly better glycaemic control.
Odds Ratio: 1.95 (95% CI 1.02–3.71)
Absolute Event Rate: 50.9% vs 34.6%
OBJECTIVE: Depression is prevalent in diabetes and is associated with increased risks of hyperglycaemia, morbidity and mortality. The effect of antidepressant medication (ADM) on glycaemic control is uncertain owing to a paucity of relevant data. We sought to determine whether the use of ADM is associated with glycaemic control in depressed patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A retrospective cohort study (n = 1399) was conducted using electronic medical record registry data of ambulatory primary care visits from 2008 to 2013. Depression and type 2 diabetes were identified from ICD-9-CM codes; ADM use was determined from prescription orders; and glycaemic control was determined from measures of glycated haemoglobin (A1c). Good glycaemic control was defined as A1c < 7.0% (53 mmol/mol). Generalized estimating equations were used to determine the effect of depression and ADM use on glycaemic control. RESULTS: Good glycaemic control was achieved by 50.9% of depressed subjects receiving ADM versus 34.6% of depressed subjects without ADM. After adjusting for covariates, depressed patients receiving ADM were twice as likely as those not receiving ADM to achieve good glycaemic control (odds ratio = 1.95; 95% confidence interval: 1.02-3.71). CONCLUSIONS: In this retrospective cohort study of a large sample of primary care patients with type 2 diabetes, ADM use was associated with improved glycaemic control.
Brieler et al. (Thu,) conducted a cohort in Type 2 diabetes and depression (n=1,399). Antidepressant medication vs. No antidepressant medication was evaluated on Good glycaemic control (A1c < 7.0%) (OR 1.95, 95% CI 1.02-3.71). Antidepressant medication use in patients with type 2 diabetes and depression was associated with increased odds of achieving good glycaemic control (OR 1.95; 95% CI 1.02-3.71).