Subclinical hypothyroidism significantly increased insulin resistance (median HOMA-IR 4.15 vs 3.55, p<0.05) in normoglycemic individuals, but not in those with newly diagnosed type 2 diabetes.
Cross-Sectional (n=1,243)
No
Does subclinical hypothyroidism increase insulin resistance in normoglycemic and newly diagnosed T2DM populations?
Subclinical hypothyroidism is associated with increased insulin resistance in normoglycemic individuals, suggesting that decreased central thyroid sensitivity may increase the risk of developing diabetes.
Absolute Event Rate: 4.15% vs 3.55%
p-value: p=<0.05
Objective: To investigate the effect of simple subclinical hypothyroidism (SCH) and type 2 diabetes mellitus (T2DM) combined with SCH on insulin resistance. Design and methods: A total of 622 people with newly diagnosed T2DM were selected as the study subjects, and 621 normoglycemic people were selected as control subjects. According to the diagnostic criteria of thyroid diseases, the subjects were divided into a normal thyroid function group and a subclinical hypothyroidism group. Both groups received a physical examination, and blood samples were collected. The measurement indexes included FPG, FINS, OGTT2hPG, OGTT2hINS, HbA1c, TC, TG, HDL-C, LDL-C, TSH, FT3 and FT4. HOMA-IR, HOMA-β, and TFQI (thyroid feedback quantile index) were calculated. Results: There was no significant difference in age or sex distribution between the T2DM group and the normoglycemic group (P>0.05). The prevalence of thyroid dysfunction in the T2DM group was significantly higher than that in the normoglycemic group (16.39% vs. 11.27%, P0.05). The BMI, waist-hip ratio and HOMA-IR values of the normoglycemic group with subclinical hypothyroidism (T2DM-SCH+ group) were significantly higher than those of the normoglycemic group with normal thyroid function (T2DM-SCH- group) (P0.05). HOMA-β values were significantly higher in the T2DM-SCH+ group than in the T2DM-SCH-, T2DM+SCH- and T2DM+SCH+ groups (P<0.05). As the TFQI value increased, the body weight, waist-hip ratio, diastolic blood pressure, FPG, OGTT2hPG and HbA1c values gradually increased in the T2DM group and normoglycemic group (P<0.05). HDL-C, FINS, OGTT2hINS and HOMA-β values gradually decreased (P<0.05). Conclusion: Subclinical hypothyroidism only increases insulin resistance in normoglycemic people. As the sensitivity of the central thyroid decreases, the risk of developing diabetes increases.
Yang et al. (Thu,) conducted a cross-sectional in Subclinical hypothyroidism and Type 2 Diabetes Mellitus (n=1,243). Subclinical hypothyroidism vs. Normal thyroid function was evaluated on HOMA-IR (Homeostasis model assessment of insulin resistance) in normoglycemic individuals (p=<0.05). Subclinical hypothyroidism significantly increased insulin resistance (median HOMA-IR 4.15 vs 3.55, p<0.05) in normoglycemic individuals, but not in those with newly diagnosed type 2 diabetes.