Pharmacological sympathetic inhibition by reserpine completely inhibited the diuretic/natriuretic effects of ANP, while surgical renal nerve denervation did not influence the renal response.
Does adrenergic modulation or renal nerve denervation alter the diuretic/natriuretic effects of ANP in normotensive rats?
ANP appears to act indirectly within the kidney via interaction with dopamine-containing neuronal or non-neuronal structures rather than direct renal nerve activity.
The effects of various adrenergic agonists and antagonists on the diuretic/natriuretic effects of rANP (103-125) were investigated in conscious and anaesthetized normotensive rats. Pharmacological sympathetic inhibition by reserpine completely inhibited the diuretic/natriuretic effects of ANP. However, surgical renal nerve denervation did not influence the renal response to ANP. Further studies using various pharmacological agents which interfere with adrenergic activity revealed that the diuretic mechanism of action differed between conscious and anaesthetized animals. In the anaesthetized group only, dopamine (D1) blockade reduced ANP-induced diuresis. In the conscious as well as anaesthetized rats, however, pre-synaptic dopamine (D2) stimulation and alpha 2-adrenergic receptor blockade effectively inhibited the renal response to ANP. The results of this study are compatible with the notion that ANP acts indirectly within the kidney via interaction with dopamine-containing neuronal or non-neuronal structures in the kidney.
Pettersson et al. (Wed,) conducted a other in Normotensive rats. Adrenergic agonists and antagonists and rANP (103-125) was evaluated on Diuretic/natriuretic effects of ANP. Pharmacological sympathetic inhibition by reserpine completely inhibited the diuretic/natriuretic effects of ANP, while surgical renal nerve denervation did not influence the renal response.
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