Postoperative recovery represents a complex, multidimensional process that extends beyond the technical success of surgery, encompassing the restoration of physiologic stability, functional capacity, and patient-centered well-being. Recovery trajectories are highly variable, influenced not only by baseline patient characteristics but also by modifiable determinants spanning physiologic, behavioral, and system-level domains. This narrative review synthesizes current evidence on the interplay among these factors, highlighting mechanistic pathways, contextual modulators, and opportunities for targeted optimization. At the patient level, physiologic reserve, including nutritional status, sarcopenia, frailty, metabolic control, and comorbidities, defines the capacity to tolerate surgical stress and engage in functional recovery. Behavioral determinants, encompassing early mobilization, structured rehabilitation, patient engagement, perioperative education, and multimodal pain management, translate physiologic potential into meaningful postoperative outcomes. These factors operate synergistically, with behavioral interventions mitigating vulnerabilities such as frailty or sarcopenia while amplifying gains from physiologic optimization. System-level determinants, including multidisciplinary perioperative pathways, coordinated surgical home models, telemonitoring platforms, and implementation science-driven frameworks, provide the structural scaffolding necessary to ensure fidelity, adaptability, and scalability of interventions. Digital health technologies and predictive analytics offer additional mechanisms to monitor recovery trajectories, identify deviations early, and personalize care in real time. The integration of patient-level, behavioral, and system-level determinants is nonlinear and context-dependent, with interactions modulated by institutional resources, patient risk profiles, and care culture. Effective perioperative optimization requires a holistic, reproducible framework that aligns physiologic enhancement, behavioral engagement, and system-level support, enabling dynamic adaptation to individual patient needs. This review emphasizes that recovery is not a passive outcome but a mechanistically coherent, modifiable, and measurable process. By conceptualizing postoperative recovery as an integrated, adaptive, and precision-guided continuum, clinicians and health systems can improve functional outcomes, reduce complications, and advance patient-centered surgical care across heterogeneous populations.
Salib et al. (Wed,) studied this question.