Background: Endodontic practitioners face a formidable obstacle in the treatment of periapical lesions, which sometimes need lengthy recovery times after traditional root canal procedures.The concentrated growth factors and fibrin matrix of platelet-rich fibrin (PRF) make it a potentially regenerative autologous biomaterial.The purpose of this research was to assess the radiographic and clinical results of using PRF in conjunction with traditional endodontic treatment for periapical lesion care.Materials and methods: A randomized controlled trial was conducted on 60 patients with chronic periapical lesions, randomly allocated into two groups.Group A (n = 30) received conventional endodontic therapy with PRF placement, while group B (n = 30) received conventional endodontic therapy alone.Clinical parameters (pain, swelling, sinus tract) and radiographic assessments periapical index (PAI) scoring, lesion size reduction were evaluated at baseline, 3, 6, and 12 months postoperatively. Results:The PRF group demonstrated significantly greater reduction in mean lesion size (68.4 ± 12.3%) compared to the control group (42.7 ± 15.6%) at 12 months (p < 0.001).Complete radiographic healing was observed in 83.3% of PRF-treated cases vs 56.7% in controls (p = 0.021).Clinical success rates were 93.3 and 76.7% for groups A and B, respectively (p = 0.038).Pain resolution was significantly faster in the PRF group (mean 4.2 ± 1.8 days vs 8.6 ± 2.4 days; p < 0.001).Conclusion: Platelet-rich fibrin has the potential to greatly improve the results of periapical lesion healing when added to traditional endodontic treatment, indicating its usefulness in regenerative endodontic regimens.
Chandwani et al. (Mon,) studied this question.