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The Story of Amiodarone | Synapse
June 19, 2026
Open Access
The Story of Amiodarone
HT
Hamed Tavolinejad
Hospital of the University of Pennsylvania
DS
Danesh Soltani
AZ
Arman Zargaran
Tehran University of Medical Sciences
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Key Points
To explore the mechanisms, therapeutic applications, and side effects of amiodarone in treating cardiovascular arrhythmias.
Narrative review of existing literature on amiodarone, its pharmacokinetics, uses, and toxicity.
Analysis of clinical studies and case reports regarding amiodarone's effectiveness and safety.
Amiodarone demonstrates significant efficacy in treating various arrhythmias.
Notable side effects include thyroid dysfunction and pulmonary toxicity, indicating the need for monitoring.
Pharmacokinetics imply a long half-life, influencing treatment duration and patient outcomes.
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Tavolinejad et al. (Sun,) studied this question.
synapsesocial.com/papers/6a35b2487f329793c62de3ce
https://doi.org/https://doi.org/10.1093/eurheartj/ehz583