Higher leisure-time physical activity (>1,000 MET-min/week) was associated with a 19% lower risk of HFpEF compared with no LTPA (HR 0.81; 95% CI 0.68-0.97), but not with HFrEF risk.
Cohort (n=51,451)
Yes
Do higher leisure-time physical activity and lower body mass index reduce the risk of overall heart failure, HFpEF, and HFrEF?
Higher leisure-time physical activity and lower body mass index are strongly associated with a lower risk of HFpEF, but these associations are less consistent for HFrEF.
Hazard Ratio: 0.81 (95% CI 0.68–0.97)
BACKGROUND: Lower leisure-time physical activity (LTPA) and higher body mass index (BMI) are independently associated with risk of heart failure (HF). However, it is unclear if this relationship is consistent for both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). OBJECTIVES: This study sought to quantify dose-response associations between LTPA, BMI, and the risk of different HF subtypes. METHODS: Individual-level data from 3 cohort studies (WHI Women's Health Initiative, MESA Multi-Ethnic Study of Atherosclerosis, and CHS Cardiovascular Health Study) were pooled and participants were stratified into guideline-recommended categories of LTPA and BMI. Associations between LTPA, BMI, and risk of overall HF, HFpEF (ejection fraction ≥45%), and HFrEF (ejection fraction 1,000 MET-min/week) were associated with an 19% lower risk of HFpEF (hazard ratio: 0.81; 95% confidence interval: 0.68 to 0.97). The dose-response relationship for BMI with HFpEF risk was also more consistent than with HFrEF risk, such that increasing BMI above the normal range (≥25 kg/m CONCLUSIONS: Our study findings show strong, dose-dependent associations between LTPA levels, BMI, and risk of overall HF. Among HF subtypes, higher LTPA levels and lower BMI were more consistently associated with lower risk of HFpEF compared with HFrEF.
“We consistently found an association between physical activity, BMI and overall heart failure risk. This was not unexpected, however the impact of these lifestyle factors on heart failure subtypes was quite different.”
Pandey et al. (Tue,) conducted a cohort in Heart failure (n=51,451). Leisure-time physical activity (LTPA) and body mass index (BMI) vs. No LTPA and normal range BMI was evaluated on Risk of overall HF, HFpEF (ejection fraction ≥45%), and HFrEF (ejection fraction <45%) (HR 0.81, 95% CI 0.68-0.97). Higher leisure-time physical activity (>1,000 MET-min/week) was associated with a 19% lower risk of HFpEF compared with no LTPA (HR 0.81; 95% CI 0.68-0.97), but not with HFrEF risk.