In older adults with chronic heart failure, a high triglyceride-glucose index was independently associated with an increased risk of heart failure rehospitalization (HR 1.63).
Cohort (n=786)
No
Does a high TyG index predict heart failure rehospitalization and all-cause mortality in geriatric patients with chronic heart failure?
In elderly patients with chronic heart failure, a higher TyG index serves as an independent predictor of heart failure rehospitalization, highlighting its potential utility in risk stratification.
Effect estimate: HR 1.63
p-value: p=<0.001
Objectives: To determine the prognostic value of the triglyceride-glucose (TyG) index, which serves as a surrogate for insulin resistance, for heart failure rehospitalization and all-cause mortality in older adults with chronic heart failure, and to evaluate its clinical utility in risk stratification and nursing care. Methods: In this single-center retrospective cohort study, 786 patients aged ≥65 years with chronic heart failure hospitalized at a tertiary referral hospital in Central China (January 2022–January 2025) were included and divided into low vs. high TyG index groups based on the median. Baseline data were extracted from medical records. Follow-up ended in December 2025. Associations between TyG index and adverse outcomes were examined using Kaplan–Meier curves, restricted cubic spline (RCS) regression, and multivariable Cox proportional hazards models. Results: The median TyG index was 8.35. In unadjusted analyses, the high-TyG group had significantly greater cumulative risks of heart failure rehospitalization (p < 0.001) and all-cause mortality (p = 0.028). After multivariable adjustment, the TyG index remained independently associated with heart failure rehospitalization (hazard ratio HR= 1.63), whereas its association with all-cause mortality was attenuated and no longer significant. Restricted cubic spline analysis revealed a nonlinear dose–response relationship between the TyG index and heart failure rehospitalization, and a linear relationship with all-cause mortality. Conclusions: In elderly patients with chronic heart failure, the TyG index independently predicted heart failure rehospitalization and demonstrated a nonlinear dose–response relationship; its independent association with all-cause mortality was not significant after full adjustment. The index may nonetheless aid in risk stratification and individualized nursing in this population.
Tian et al. (Sat,) conducted a cohort in Chronic heart failure (n=786). High triglyceride-glucose (TyG) index vs. Low TyG index was evaluated on Heart failure rehospitalization and all-cause mortality (HR 1.63, p=<0.001). In older adults with chronic heart failure, a high triglyceride-glucose index was independently associated with an increased risk of heart failure rehospitalization (HR 1.63).