Transcatheter aortic valve implantation significantly improved physical (28.3 to 42.4) and mental (38.0 to 48.2) quality-of-life scores at 12 months in elderly patients (p<0.001).
Cohort (n=143)
No
Does transcatheter aortic valve implantation (TAVI) improve quality of life in elderly patients with severe aortic stenosis?
TAVI provides significant and sustained improvements in both physical and mental quality of life at 1 year in elderly patients with severe aortic stenosis, reaching levels comparable to the general elderly population.
p-value: p=<0.001
AIMS: Transcatheter aortic valve implantation (TAVI) is an emerging alternative to medical therapy reserved to a limited population with severe aortic stenosis. Quality-of-life (QoL) is a critical measure of effectiveness of TAVI in this patient population. In this prospective study, we sought to assess one year changes in QoL in patients who underwent TAVI. METHODS AND RESULTS: From June 2007 to July 2010, 149 consecutive patients underwent TAVI using the 18 Fr CoreValve (Medtronic Inc, Minneapolis, MN, USA) or the Edwards SAPIEN XT heart valve (Edwards Lifescience, Irvine, CA, USA) at our institution. Of these, 143 patients with successful prosthesis implantation comprised the study population. The SF-12v2 Health-Survey questionnaire provides scales for physical (physical component summary PCS) and mental (mental component summary MCS) health. Among patients included in the present analysis, device success was obtained in 138 patients (96.5%). Mean preprocedural SF-12v2 scores showed an important upgrading after TAVI: PCS improved from 28.3 to 44.0 at five months and 42.4 at 12 months (p<0.001). MCS increased from 38.0 to 47.3 at five months and 48.2 at 12 months (p<0.001). Both the physical and mental score summaries at follow-up of these post-TAVI patients were not significantly different from the anticipated thresholds of the general Italian population over the age of 75 years. NYHA functional class improvement was reported in all patients. CONCLUSIONS: Our results showed a marked mid-term improvement in functional status and physical and mental health in patients who underwent TAVI.
Ussia et al. (Thu,) conducted a cohort in Severe aortic stenosis (n=143). Transcatheter aortic valve implantation (TAVI) vs. Baseline (preprocedural) was evaluated on Quality-of-life (SF-12v2 physical and mental component summaries) (p=<0.001). Transcatheter aortic valve implantation significantly improved physical (28.3 to 42.4) and mental (38.0 to 48.2) quality-of-life scores at 12 months in elderly patients (p<0.001).
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