Age was associated with a small but significant increase in collagen gel in the subendocardial and subpericardial zones of the interventricular septum, but not in the central zone.
Cross-Sectional (n=40)
Myocardial collagen content increases slightly with age specifically in the subendocardial and subpericardial zones, but not in the central myocardial zone.
An automated flying spot microscope has been used to estimate the volume proportion of collagen gel in myocardium. Observations were limited to the interventricular septum and 40 specimens were examined, nearly all from normal hearts in the age range 13—92 yr. A small but significant increase with age was found for collagen gel in regions in which the muscle fibres were predominantly transverse — that is, in the subendocardial and subpericardial zones — although there was no significant increase where they were predominantly longitudinal — that is, in the central myocardial zone.
LENKIEWICZ et al. (Fri,) conducted a cross-sectional in Normal hearts (n=40). Age was evaluated on Volume proportion of collagen gel in myocardium. Age was associated with a small but significant increase in collagen gel in the subendocardial and subpericardial zones of the interventricular septum, but not in the central zone.