November 29, 1990
View Full PaperAtrial Fibrillation — Risk Marker for Stroke
Key Result
Nonvalvular atrial fibrillation is associated with a fivefold increase in the risk of ischemic stroke, with cerebral infarction eventually occurring in up to 35 percent of patients.
Structured PICO
P
Population
Patients with nonvalvular atrial fibrillation
Nonvalvular atrial fibrillation is a major risk marker for stroke, associated with a fivefold increase in ischemic stroke risk.
Main Result
Relative Risk: 5
Abstract
Atrial fibrillation not related to valvular heart disease (nonvalvular atrial fibrillation) is associated with nearly half the arterial emboli presumed to be of cardiac origin. It starts at a mean age of 64 years, affects 2 to 5 percent of the general population over the age of 60 (more than 1 million people), and is associated with a fivefold increase in the risk of ischemic stroke and a 5 to 7 percent yearly risk that increases with age. Cerebral infarction eventually occurs in up to 35 percent of patients with nonvalvular atrial fibrillation. The risk is even higher if "silent" . . .