What does this research mean for the field?

Aptamer-based techniques, such as SOMAscan assays, provide a scalable and multiplexed alternative to traditional antibody-based methods for measuring the highly complex human plasma proteome. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the effectiveness of aptamer assays for measuring proteins in human plasma.

July 24, 2026Open Access

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In Aptamers They Trust

AJAbhishek JoshiBarts Health NHS Trust MMManuel MayrVascular Medicine

Key Points

This research aims to evaluate the effectiveness of aptamer assays for measuring proteins in human plasma.
Utilized SOMAscan aptamer assays for protein measurement.
Focused on the complexities of the plasma proteome, including variants and modifications.
Compared aptamer techniques against traditional antibody-based methods.
Aptamer assays showed improved scalability for multiplexed protein measurement.
Identified significant variations due to splice variants and posttranslational modifications in plasma samples.
Demonstrated potential advantages over conventional antibody techniques for proteomic analysis.

Abstract

lthough it has become affordable to sequence the entire human genome, measuring all proteins in a sample as complex as human plasma remains currently out of reach. The plasma proteome has an enormous dynamic range and variability, including splice variants, cleavage products, and posttranslational modifications. Antibody-based techniques have predominated, but other affinity-based techniques such as the SOMAscan aptamer assays from SomaLogic also promise the multiplexed measurement of proteins in a scalable manner.

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Cite This Study

Joshi et al. (Tue,) studied this question.

synapsesocial.com/papers/6a63d6d215f73d3e5bf28522 https://doi.org/https://doi.org/10.1161/circulationaha.118.036823

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