Patients without post-stroke depression were more likely to show excellent recovery on activities of daily living (OR 1.95; 95% CI 1.01-3.75) and mobility compared to those with depression.
Case-Control (n=290)
Does poststroke depression affect functional status and rehabilitation recovery in stroke inpatients?
Poststroke depression negatively impacts functional recovery and mobility in stroke patients undergoing rehabilitation, despite pharmacological treatment.
Odds Ratio: 1.95 (95% CI 1.01–3.75)
The aim of this study was to assess the specific influence of poststroke depression (PSD) on both basal functional status and rehabilitation results. We performed a case-control study in 290 stroke inpatients, matched for age (+/-1 year) and onset admission interval (+/-3 days) and divided in two groups according to the presence (PSD+) or absence (PSD-) of PSD. All PSD+ patients were treated with antidepressants (AD), mainly with fluoxetine. PSD+ patients, despite similar severity of stroke, showed greater disability in coping with activities of daily living (ADL) on admission and greater disability both in ADL and mobility at discharge than PSD- patients. Although both groups exhibited similar average functional improvement during rehabilitation, PSD- patients were nearly twice as likely to show excellent recovery both on ADL and mobility as PSD+ patients (OR = 1.95, 95% CI = 1.01-3.75 and OR = 2.23, 95% CI = 1.14-4.35, respectively). All AD drugs improved depressive symptoms. Few relevant side effects were observed: fluoxetine was discontinued in 2 patients because of insomnia and in 2 patients because of nausea; paroxetine was stopped in 1 patient because of nausea and dry mouth. Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment.
Paolucci et al. (Mon,) conducted a case-control in Stroke (n=290). Post-stroke depression (PSD) vs. Absence of post-stroke depression (PSD-) was evaluated on Excellent recovery on activities of daily living (ADL) (OR 1.95, 95% CI 1.01-3.75). Patients without post-stroke depression were more likely to show excellent recovery on activities of daily living (OR 1.95; 95% CI 1.01-3.75) and mobility compared to those with depression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: