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Abstract Highly electronically deactivated benzylic alcohols, including those with a CF 3 group adjacent to the OH‐bearing carbon, undergo dehydrative Friedel–Crafts reactions upon exposure to catalytic Brønsted acid in 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) solvent. Titration and kinetic experiments support the involvement of higher order solvent/acid clusters in catalysis.
Vuković et al. (Fri,) studied this question.
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