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Our study elucidated the molecular mechanism by which KRAS-G12D mutation drives immunosuppression and enhances resistance of ICIs in NSCLC. Importantly, our findings demonstrate that ICIs in combination with chemotherapy may be more effective in patients with KRAS-G12D-mutant NSCLC.
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Chengming Liu
Chinese Academy of Medical Sciences & Peking Union Medical College
Sufei Zheng
Chinese Academy of Medical Sciences & Peking Union Medical College
Zhanyu Wang
Chinese Academy of Medical Sciences & Peking Union Medical College
Cancer Communications
SHILAP Revista de lepidopterología
Chinese Academy of Medical Sciences & Peking Union Medical College
Peking Union Medical College Hospital
National Clinical Research
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Liu et al. (Mon,) studied this question.
synapsesocial.com/papers/69dd4c8a0644c7b49d40cc13 — DOI: https://doi.org/10.1002/cac2.12327