Does left ventricular stiffness modulate end-diastolic pressure and stroke volume during physiological stress in patients with HFNEF?
Patients with Heart Failure With Normal Ejection Fraction (HFNEF)
Handgrip exercise and atrial pacing
End-diastolic pressure and stroke volumesurrogate
Left ventricular stiffness modulates cardiac function during stress in HFNEF, highlighting it as a potential therapeutic target.
Increased left ventricular stiffness contributed to increased end-diastolic pressure during handgrip exercise and decreased stroke volume during atrial pacing in patients with HFNEF. These data suggest that left ventricular stiffness modulates cardiac function in HFNEF patients and suggests that diastolic dysfunction with increased stiffness is a target for treating HFNEF.
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Dirk Westermann
Heart Failure & Transplant
Mario Kašner
Heart Failure & Transplant
Paul Steendijk
Heart Failure & Transplant
Circulation
Leiden University Medical Center
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Westermann et al. (Mon,) studied this question.
synapsesocial.com/papers/69de7cf9fd84e72eb25585cc — DOI: https://doi.org/10.1161/circulationaha.107.716886