Delayed disulfiram targeting GSDMD-NETs axis rescues sepsis by limiting bacterial spread and lung injury

Key Points

• Delayed treatment with disulfiram significantly reduces bacterial spread, improving outcomes in sepsis.
• In the experiments, disulfiram treatment resulted in reduced lung injury markers after sepsis induction.
• Assessment using specific animal models demonstrated the efficacy of disulfiram on the GSDMD-NETs axis in sepsis.
• This approach highlights the need for further clinical evaluation to confirm efficacy in human patients; mouse model used.