March 11, 2026Open Access

Mechanism-based prediction of drug synergy via network controllability analysis of therapeutic pathways in intractable diseases

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Abstract

experiments and multi-resolution omics analyses of human cohort data at bulk and single-cell levels. SYNERGIE offers a mechanism-aware approach to identifying clinically viable combination therapies, and is expected to support stratified treatment of intractable diseases.

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Authors

Satoko Namba

Nagoya University

Mitsuhiro Goda

Hiroshima University

Yurika Kuniki

Tokushima University Hospital

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iScience

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Nagoya University

National Institute of Advanced Industrial Science and Technology

Hiroshima University

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Namba et al. (Wed,) studied this question.

synapsesocial.com/papers/6a08fc16a2bc65e38873b0cf — DOI: https://doi.org/10.1016/j.isci.2026.115339

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SuperTarget and Matador: resources for exploring drug-target relationships· 2007 · 664 citations
Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner· 2017 · 10 citations
What is synergy?· 1989 · 478 citations
Exploring Network Structure, Dynamics, and Function using NetworkX· 2008 · 7,343 citations
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles· 2017 · 3,683 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

SuperTarget and Matador: resources for exploring drug-target relationships· 2007 · 664 citations
Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner· 2017 · 10 citations
What is synergy?· 1989 · 478 citations
Exploring Network Structure, Dynamics, and Function using NetworkX· 2008 · 7,343 citations
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles· 2017 · 3,683 citations

Mechanism-based prediction of drug synergy via network controllability analysis of therapeutic pathways in intractable diseases

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

Cite this study

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