March 15, 2026Open Access

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012–2022

Key Points

To investigate the association of iatrogenic withdrawal with opioid and benzodiazepine weaning in children with bronchiolitis.
Single-center, retrospective cohort study from 2012 to 2022
Analysis of cumulative IV opioid dose and weaning protocols
Assessment of withdrawal risk based on CCC-V2 categories
Higher cumulative IV opioid doses linked to increased withdrawal odds
Recent IV opioid weaning within 8-12 hours correlated with withdrawal
Morphine usage associated with significantly higher odds of withdrawal

Abstract

Patients with a higher cumulative IV opioid dose, an IV opioid wean in the preceding 8-12 hours, and greater than or equal to 2 CCC-V2 categories had the highest odds of withdrawal in this single-center study. Morphine was associated with increased odds of withdrawal as well.

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Authors

Alice Shanklin

Children's National

Eduardo A. Trujillo Rivera

Murray M. Pollack

George Washington University Hospital

Journals

Critical Care Explorations

Actions

Institutions

George Washington University

Children's National

Cohen Children's Medical Center

References and Citations

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Discussion

Cite this study

Shanklin et al. (Sun,) studied this question.

synapsesocial.com/papers/69b6069b83145bc643d1c9dd — DOI: https://doi.org/10.1097/cce.0000000000001391

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Patient, Provider, and Health Care System Characteristics Associated With Overuse in Bronchiolitis· 2021 · 14 citations
An Antiracism Approach to Conducting, Reporting, and Evaluating Pediatric Critical Care Research· 2022 · 53 citations
Sedation and Analgesia for Procedures in Children· 2000 · 466 citations
New Equations to Estimate GFR in Children with CKD· 2009 · 3,733 citations
Bronchiolitis Management Before and After the AAP Guidelines· 2013 · 159 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Patient, Provider, and Health Care System Characteristics Associated With Overuse in Bronchiolitis· 2021 · 14 citations
An Antiracism Approach to Conducting, Reporting, and Evaluating Pediatric Critical Care Research· 2022 · 53 citations
Sedation and Analgesia for Procedures in Children· 2000 · 466 citations
New Equations to Estimate GFR in Children with CKD· 2009 · 3,733 citations
Bronchiolitis Management Before and After the AAP Guidelines· 2013 · 159 citations

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012–2022

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider