Does chymase inhibition prevent myocardial fibrosis and oxidative stress in diabetic hamsters?
Chymase inhibition may prevent diabetic cardiomyopathy and myocardial fibrosis by reducing oxidative stress and local AngII production in a diabetic hamster model.
Chymase inhibition might prevent oxidative stress and diabetic cardiomyopathy at an early stage by reducing local AngII production. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00202.x, 2012).
Maeda et al. (Tue,) studied this question.