Non-invasive cardiovascular magnetic resonance-derived ventricular vascular coupling ratio was significantly correlated with catheterization-derived estimates (r = 0.79) and accurately predicted vascular reactivity in pediatric patients with pulmonary hypertension.
Observational (n=17)
No
Does non-invasive cardiovascular magnetic resonance accurately determine right ventricular-vascular coupling compared to invasive catheterization in children and adolescents with pulmonary hypertension?
Non-invasive measurement of right ventricular-vascular coupling using CMR is feasible and highly correlates with invasive catheterization measurements in pediatric pulmonary hypertension.
Effect estimate: r = 0.79 (95% CI 0.48-0.99)
p-value: p=<0.0001
BACKGROUND: Pediatric pulmonary hypertension (PH) remains a disease with high morbidity and mortality in children. Understanding ventricular-vascular coupling, a measure of how well matched the ventricular and vascular function are, may elucidate pathway leading to right heart failure. Ventricular vascular coupling ratio (VVCR), comprised of effective elastance (Ea, index of arterial load) and right ventricular maximal end-systolic elastance (Ees, index of contractility), is conventionally determined by catheterization. Here, we apply a non-invasive approach to determining VVCR in pediatric subjects with PH. METHODS: This retrospective study included PH subjects who had a cardiovascular magnetic resonance (CMR) study within 14 days of cardiac catheterization. PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg on prior or current catheterization. A non-invasive measure of VVCR was derived from CMR-only (VVCRm) and compared to VVCR estimated by catheterization-derived single beat estimation (VVCRs). Indexed pulmonary vascular resistance (PVRi) and pulmonary vascular reactivity were determined during the catheterization procedure. Pearson correlation coefficients were calculated between PVRi and VVCRm. Receiver operating characteristic (ROC) curve analysis determined the diagnostic value of VVCRm in predicting vascular reactivity. RESULTS: Seventeen subjects (3 months-23 years; mean 11.3 ± 7.4 years) were identified between January 2009-August 2013 for inclusion with equal gender distributions. Mean mPAP was 35 mmHg ± 15 and PVRi was 8.5 Woods unit x m2 ± 7.8. VVCRm (range 0.43-2.82) increased with increasing severity as defined by PVRi (p < 0.001), and was highly correlated with PVRi (r = 0.92, 95 % CI 0.79-0.97, p < 0.0001). Regression of VVCRm and PVRi demonstrated differing lines when separated by reactivity. VVCRm was significantly correlated with VVCRs (r = 0.79, CI 0.48-0.99, p <0.0001). ROC curve analysis showed high accuracy of VVCRm in determining vascular reactivity (VVCR = 0.85 had a sensitivity of 100 % and a specificity of 80 %) with an area under the curve of 0.89 (p = 0.008). CONCLUSION: Measurement of VVCRm in pediatrics is feasible. Pulmonary vascular non-reactivity may be contribute to ventricular-vascular decoupling in severe PH. Therapeutic intervention to maintain a low vascular afterload in reactive patients may preserve right ventricular functional reserve and delay the onset of RV-PA decoupling. Use of VVCRm may have significant prognostic implication.
Truong et al. (Thu,) conducted a observational in Pulmonary hypertension (n=17). Cardiovascular magnetic resonance-derived ventricular vascular coupling ratio (VVCRm) vs. Catheterization-derived single beat estimation (VVCRs) was evaluated on Correlation between CMR-derived VVCR (VVCRm) and catheterization-derived VVCR (VVCRs) (r = 0.79, 95% CI 0.48-0.99, p=<0.0001). Non-invasive cardiovascular magnetic resonance-derived ventricular vascular coupling ratio was significantly correlated with catheterization-derived estimates (r = 0.79) and accurately predicted vascular reactivity in pediatric patients with pulmonary hypertension.