Are beta-blockers associated with a lower rate of cardiac and fatal or near-fatal events in catecholaminergic polymorphic ventricular tachycardia probands and affected family members?
Catecholaminergic polymorphic ventricular tachycardia probands and affected family members
Beta-blockers
Cardiac and fatal or near-fatal eventshard clinical
Despite beta-blocker therapy lowering event rates, CPVT patients still experience significant rates of fatal or near-fatal cardiac events, highlighting the need for additional therapies.
Cardiac and fatal or near-fatal events were not rare in both catecholaminergic polymorphic ventricular tachycardia probands and affected family members during the long-term follow-up, even while taking beta-blockers, which was associated with a lower event rate. Further studies evaluating concomitant therapies are necessary to improve outcome in these patients.
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Meiso Hayashi
Isabelle Denjoy
Fabrice Extramiana
Circulation
Université Paris Cité
Centre Hospitalier Universitaire de Grenoble
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Hayashi et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69d573c85883a1e80be3bc36 — DOI: https://doi.org/10.1161/circulationaha.108.829267