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Rabbits were exposed to carbon monoxide at varying concentrations and for varying lengths of time in order to estimate the threshold limit value for myocardial damage. Degenerative changes were seen in rabbits exposed for more than 4h to CO concentrations higher than 100 ppm. This high sensitivity of the myocardium to CO is explained by the combination of the binding of CO to myoglobin and the prevailing low oxygen tension in the normal myocardium. The study suggests that the CO content in tobacco smoke and in polluted air may be deleterious to persons with ischaemic heart disease. A reevaluation of the recommended threshold limit for industrial CO exposure is proposed.
Thomsen et al. (Thu,) studied this question.
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