Anatomic differences in cellular organization and membrane structures provide a basis for understanding normal and abnormal impulse generation and conduction in the heart.
An examination of the anatomy of the atrial, ventricular, and Purkinje cells reveals that the internal composition of all cardiac myofibers is qualitatively the same: all have a single nucleus, sarcomeric and mitochondrial units, and a well-developed sarcoplasmic reticulum. There are important differences, however, in the extent and distribution of the cell membrane and its derivatives in the myofiber. The presence or absence of a transverse tubular system and the variation in the number and type of intercellular linkages explain at least some of the characteristic electrical and functional properties of individual types of cells. The overall pattern of cellular organization in working atrial, ventricular, and conducting tissue is reviewed, and possible anatomic bases for current theories of normal and abnormal impulse generation and conduction in the heart are discussed.
Marianne J. Legato (Mon,) studied this question.
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