Mouse and Human Granzyme B Have Distinct Tetrapeptide Specificities and Abilities to Recruit the Bid Pathway

Granzyme B is an important mediator of cytotoxic lymphocyte granule-induced death of target cells, accomplishing this through cleavage of Bid and cleavage and activation of caspases as well as direct cleavage of downstream substrates. Significant controversy exists regarding the primary pathways used by granzyme B to induce cell death, perhaps arising from the use of different protease/substrate combinations in different studies. The primary sequence of human, rat, and mouse granzymes B is well conserved, and the substrate specificity and crystal structure of the and is the substrate specificity of mouse granzyme from the the of and mouse granzymes B and mouse granzyme B the substrates. The of and mouse granzyme B in the of cleavage of granzyme B mouse to cleavage by the mouse the Bid is primary mediator of the of mouse granzyme important the substrate specificity and of the granzyme B in different and is and different of granzyme Granzyme B is an important mediator of cytotoxic lymphocyte granule-induced death of target cells, accomplishing this through cleavage of Bid and cleavage and activation of caspases as well as direct cleavage of downstream substrates. Significant controversy exists regarding the primary pathways used by granzyme B to induce cell death, perhaps arising from the use of different protease/substrate combinations in different studies. The primary sequence of human, rat, and mouse granzymes B is well conserved, and the substrate specificity and crystal structure of the and is the substrate specificity of mouse granzyme from the the of and mouse granzymes B and mouse granzyme B the substrates. 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