New NICE guidelines for hypertension

OBJECTIVE: In a prospective cohort of 704 Hispanics, we sought to investigate the association between 13 candidate genes and cognitive performance. BACKGROUND: Focusing on individuals of Western European origin, previous genetic studies have demonstrated that cognition is highly heritable and impacted by many genes. DESIGN/METHODS: The Northern Manhattan Study contains a subgroup of 704 stroke-free Hispanics (mean age 69), who were genotyped using the AffyMetrix Genome-Wide Human single nucleotide polymorphism (SNP) Array 6.0. Participants underwent a baseline neuropsychological evaluation. Test scores were Z-transformed and grouped into four factor analysis-derived domains: executive function, episodic memory, semantic memory, and processing speed. Linear regression analyses were performed between each SNP and cognitive domain after adjusting for age, sex, years of education, testing language, insurance status, and ancestry (top two principal components from Eigenstrat). Fully adjusted linear regression analyses were also performed to see if the SNPs were effect modifiers of age-related variability in cognitive performance. RESULTS: In the fully adjusted models, accounting for SNPs in linkage disequilibrium and applying a modified Bonferonni correction (PDisclosure: Dr. Katz has nothing to disclose. Dr. Dong has nothing to disclose. Dr. Stern has received personal compensation for activities with Elan, Bayer Pharmaceuticals Corporation, Cephalon, and GalaxoSmithKlein as a consultant. Dr. Wright has received royalty payments from UpToDate. Dr. Blanton has nothing to disclose. Dr. Sacco has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals.