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Nasal mucus flow rate, airway resistance, and subjective response was studied in 15 young men during six-hour exposures to 1, 5, and 25 ppm sulfur dioxide (SO2). A significant decrease in nasal mucus flow rate during 5- and 25-ppm exposures was observed. This decrease was greatest in the anterior nose and in subjects with an initially slow mucus flow rate. Pharyngeal air samples yielded less than 1% of the SO2 inhaled, even after a six-hour exposure to 25 ppm SO2. An increased nasal airflow resistance and a fall in forced expiratory volume in one second and forced expiratory flow during the middle half of expired volume was found at all exposure levels, but there was no change in “closing volume.” Discomfort was proportional to SO2 concentration, but never excessive. Subjects with initially slow nasal mucus flow rates experienced the greatest discomfort. The acute effects of SO2 exposure appear to justify reduction of the present threshold limit value of 5 ppm to 1 ppm, and provide support for a nasobronchial reflex bronchoconstriction.
Andersen et al. (Tue,) studied this question.