Does oxidative stress contribute to large elastic arterial stiffening across the stages of the menopausal transition in healthy women?
Oxidative stress contributes to arterial stiffening during the menopausal transition, though the relative contributions of ovarian function loss versus aging remain unclear.
Arterial stiffening worsens across the stages of the menopausal transition in healthy women. This seems to be mediated, in part, by oxidative stress, particularly during the late perimenopausal and postmenopausal periods. It remains uncertain whether this is specifically caused by loss of ovarian function or aging.
Hildreth et al. (Tue,) studied this question.