Maximal exercise hemodynamics and risk of mortality in apparently healthy men and women

The purpose of this investigation was to determine the association of maximal exercise hemodynamic responses with risk of mortality due to all-causes, cardiovascular disease (CVD), and coronary heart disease (CHD) in a population of apparently healthy individuals. Study participants were 20,387 men (mean age = 42.2 yr) and 6,234 women (mean age = 41.9 yr), patients of a preventive medicine center in Dallas, TX, examined between 1971 and 1989. Maximal heart rate and maximal systolic blood pressure (SBP) measured during the maximal exercise test were related to risk of all-cause, CVD, and CHD mortality. During an average of 8.1 yr of follow-up, there were 348 deaths in men and 66 deaths in women. Among men, after adjustment for confounding variables, risks (and 95 percent confidence interval (CI)) of all-cause mortality for quartiles of maximal SBP, relative to the lowest quartile, were: 0.96 (0.70-1.33), 1.36 (1.01-1.85), and 1.37 (0.98-1.92) for quartiles 2-4, respectively. Similarly adjusted risks for maximal heart rate were: 0.61(0.44-0.85), 0.69 (0.51-0.93), and 0.60 (0.41-0.87). Similar results were seen for risk of CVD and CHD death. In women, similar trends in adjusted risks of all-cause and CVD mortality across maximal SBP and heart rate categories were observed. For maximal heart rate, a 35 bpm higher value was associated with a 36 percent decreased risk of CVD mortality in men (RR = 0.63,95 percent CI = 0.34-0.71) and an 8 percent lower risk in women (RR = 0.92,95 percent CI = 0.18-4.63). These results suggest that an exaggerated SBP or an attenuated heart rate response to maximal exercise may indicate an elevated risk for mortality in this apparently healthy population.