Acute normovolemic hemodilution to a hematocrit of 21-29% in patients undergoing total hip replacement was well tolerated, increased cardiac output to 123-136%, and reduced homologous blood use.
Case Report (n=4)
The effects of acute normovolemic hemodilution on hemodynamics, oxygen transport, tissue perfusion and blood volume were studied. The subjects were four patients undergoing total hip replacement with prebleeding and hemodilution under fluoroxene and nitrous oxide anesthesia. The hematocrit was reduced to 29% and 21% by bleeding in two steps with simultaneous infusion of plasmanate and lactated Ringer's solution. The major compensation was a rise in CO to 123% and 136%. Systemic oxygen transport (COX arterial O(2) content) was only slightly reduced and the arteriovenous oxygen difference decreased. Tissue perfusion remained excellent. Blood volume was slightly expanded. The procedure was well tolerated by this group of selected patients, and homologous blood utilization was markedly reduced.
MKS et al. (1974) conducted a case report in Total hip replacement (n=4). Acute normovolemic hemodilution was evaluated on Hemodynamics, oxygen transport, tissue perfusion, and blood volume. Acute normovolemic hemodilution to a hematocrit of 21-29% in patients undergoing total hip replacement was well tolerated, increased cardiac output to 123-136%, and reduced homologous blood use.
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