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Supramolecular aggregates of DNA, RNA, streptavidin, immunoglobulin, and nanocrystalline metal clusters can be generated by self-assembly on the basis of oligonucleotide hybridization (shown schematically). Following selective immunosorption on surface-immobilized antigen, the biometallic hybrid is detectable by electron microscopy.
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Christof M. Niemeyer
Karlsruhe Institute of Technology
Wolfgang Bürger
University of Groningen
Jörg Peplies
Ribocon (Germany)
Angewandte Chemie International Edition
University of Bremen
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Niemeyer et al. (Fri,) studied this question.
synapsesocial.com/papers/6a10132efa36b6e053fd350e — DOI: https://doi.org/10.1002/(sici)1521-3773(19980904)37:16<2265::aid-anie2265>3.0.co;2-f