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Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.
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Sonia Sharma
Benjamin R. tenOever
Nathalie Grandvaux
Science
Jewish General Hospital
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Sharma et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69dae9c5498b35d3e6a3bfc4 — DOI: https://doi.org/10.1126/science.1081315