The AT(2)-R gene A/C(3123) C allele was associated with decreased left ventricular mass index in women with hypertrophic cardiomyopathy (152 g/m2 for CC vs 211 g/m2 for AA; P=0.015).
Observational (n=103)
Does the AT(2)-R gene A/C(3123) polymorphism affect left ventricular mass index in subjects with hypertrophic cardiomyopathy?
The AT(2)-R gene A/C(3123) polymorphism is associated with reduced left ventricular mass index in women with hypertrophic cardiomyopathy, suggesting AT(2) receptors mediate antitrophic effects.
Effect estimate: beta=-30.7
p-value: p=0.010
The development of left ventricular hypertrophy in subjects with hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for modifying factors such as angiotensin II. Angiotensin II mediates both trophic and antitrophic effects, via angiotensin II type 1 (AT(1)-R) and angiotensin II type 2 (AT(2)-R) receptors, respectively. Here we investigated the effect of the AT(2)-R gene A/C(3123) polymorphism, located in the 3' untranslated region of exon 3, on left ventricular mass index (LVMI) in 103 genetically independent subjects with HCM (age, 12 to 81 years). LVMI and interventricular septum thickness were determined by 2D echocardiography. Extent of hypertrophy was quantified by a point score (Wigle score). Plasma prorenin, renin, and ACE were determined by immunoradiometric or fluorometric assays, and genotyping was performed by polymerase chain reaction. In men, no associations between AT(2)-R genotype and any of the measured parameters were observed, whereas in women, LVMI decreased with the number of C alleles (211+/-19, 201+/-18, and 152+/-10 g/m(2) in women with the AA, AC, and CC genotype, respectively; P=0.015). Similar C allele-related decreases in women were observed for interventricular septum thickness (P=0.13), Wigle score (P=0.05), plasma renin (P=0.03), and plasma prorenin (P=0.26). Multiple regression analysis revealed that the AT(2)-R C allele-related effect on LVMI (beta=-30.7+/-11.1, P=0.010) occurred independently of plasma renin, the AT(1)-R gene A/C(1166) polymorphism, or the ACE gene I/D polymorphism. In conclusion, AT(2)-Rs modulate cardiac hypertrophy in women with HCM, independently of the circulating renin-angiotensin system. These data support the contention that AT(2)-Rs mediate antitrophic effects in humans.
Deinum et al. (Sat,) conducted a observational in Hypertrophic cardiomyopathy (n=103). AT(2)-R gene A/C(3123) polymorphism vs. AA vs AC vs CC genotypes was evaluated on Left ventricular mass index (LVMI) (beta=-30.7, p=0.010). The AT(2)-R gene A/C(3123) C allele was associated with decreased left ventricular mass index in women with hypertrophic cardiomyopathy (152 g/m2 for CC vs 211 g/m2 for AA; P=0.015).