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Four-fold: Not just the identification, but also the rapid characterization and classification of nucleic acid G-quadruplexes into topology groups is feasible utilizing UV and circular dichroism (CD) spectroscopy (see picture). It is now possible to utilize inexpensive UV spectroscopy to achieve the same level of characterization previously only possible with CD spectroscopy.
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Andreas Ioannis Karsisiotis
Nason Maani
Ettore Novellino
Angewandte Chemie International Edition
University of Bologna
University of Naples Federico II
University of Ulster
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Karsisiotis et al. (Fri,) studied this question.
www.synapsesocial.com/papers/6a03c4fa9a07eb65d5a9c4ba — DOI: https://doi.org/10.1002/anie.201105193