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The association of biomarker expression with survival varies substantially between subtypes, and can easily be overlooked in whole cohort analyses. To avoid this effect, each subtype within a cohort should be analyzed discretely. Ovarian carcinoma subtypes are different diseases, and these differences should be reflected in clinical research study design and ultimately in the management of ovarian carcinoma.
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Martin Köbel
University of Calgary
Steve E. Kalloger
Jikei University School of Medicine
Niki Boyd
University of British Columbia
SHILAP Revista de lepidopterología
PLoS Medicine
Georgia Institute of Technology
Charité - Universitätsmedizin Berlin
BC Cancer Agency
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Köbel et al. (Wed,) studied this question.
synapsesocial.com/papers/69dcace47873f5f05b1338b2 — DOI: https://doi.org/10.1371/journal.pmed.0050232
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