Is circulating ox-LDL associated with fibrocalcific remodelling of the aortic valve in patients with aortic stenosis?
Patients with aortic stenosis (AS)
Circulating oxidised low-density lipoprotein (ox-LDL)
Fibrocalcific remodelling of valvular tissuesurrogate
Increased circulating ox-LDL is associated with worse fibrocalcific remodeling of the aortic valve in patients with aortic stenosis, though its causal role remains to be determined.
Increased level of circulating ox-LDL is associated with worse fibrocalcific remodelling of valvular tissue in AS. It remains to be determined whether circulating ox-LDL is a risk marker for a highly atherogenic profile and/or a circulating molecule which is actively involved in the pathogenesis of calcific aortic valve disease.
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Claudia Côté
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
P. Pibarot
Institut Universitaire de Cardiologie et de Pneumologie de Québec
JP Després
Pennington Biomedical Research Center
Heart
Université Laval
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Côté et al. (Thu,) studied this question.
synapsesocial.com/papers/69d5721a75589c71d767e4d1 — DOI: https://doi.org/10.1136/hrt.2007.125740