July 11, 2012Open Access

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

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Abstract

We found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment. Our results require confirmation with the use of longitudinal data and may not apply to patients with sporadic Alzheimer's disease. (Funded by the National Institute on Aging and others; DIAN ClinicalTrials.gov number, NCT00869817.).

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Authors

Randall J. Bateman

Ulsan College

Chengjie Xiong

Washington University in St. Louis

Tammie L.S. Benzinger

Washington University in St. Louis

Journals

New England Journal of Medicine

Australasian Journal of Paramedicine

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Harvard University

Columbia University

University of California, San Diego

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Bateman et al. (Wed,) studied this question.

synapsesocial.com/papers/69db29ee4a1e15904c8371c1 — DOI: https://doi.org/10.1056/nejmoa1202753

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Clinical Dementia Rating training and reliability in multicenter studies· 1997 · 381 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

“Mini-mental state”· 1975 · 86,726 citations
Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families· 2012 · 329 citations
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B· 2004 · 4,470 citations
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation· 1997 · 254 citations
Clinical Dementia Rating training and reliability in multicenter studies· 1997 · 381 citations

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

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Abstract

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Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

Cite this study

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