Artificial intelligence—the third revolution in pathology

Histopathology has undergone major changes firstly with the introduction of Immunohistochemistry, and latterly with Genomic Medicine.We argue that a third revolution is underway: Artificial Intelligence (AI).Coming on the back of Digital Pathology (DP), the introduction of AI has the potential to both challenge traditional practice and provide a totally new realm for pathology diagnostics.Hereby we stress the importance of certified pathologists having learned from the experience of previous revolutions and be willing to accept such disruptive technologies, ready to innovate and actively engage in the creation, application and validation of technologies and oversee the safe introduction of AI into diagnostic practice.