High intensity interval training significantly reduced cardiac output by 21% during prolonged submaximal exercise in patients with type 2 diabetes compared to standard care.
RCT (n=26)
Open-label
Randomized
No
Does 12 weeks of high intensity interval training reduce cardiac output during prolonged submaximal exercise in patients with type 2 diabetes?
High intensity interval training in patients with type 2 diabetes reduces cardiac output and heart rate during prolonged submaximal exercise, suggesting a cardioprotective adaptation to metabolic demand.
Absolute Event Rate: 12.8% vs 16.3%
p-value: p=0.05
AIM: The present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes. METHODS: Twenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60 min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention. RESULTS: At baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.3 ± 6.1 vs. 21.7 ± 5.5 ml/kg/min, p = 0.21), and peak exercise heart rate (156.3 ± 15.0 vs. 153.8 ± 12.5 beats/min, p = 0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 ± 2.4 vs. 15.2 ± 2.2 ml/min/kg, p = 0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 ± 2.7-12.8 ± 3.6 L/min, p = 0.03), but not in the control group (15.7 ± 4.9-16.3 ± 4.1 L/min, p = 0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p = 0.03) and heart rate by 9% (p = 0.04). CONCLUSION: Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes. TRIAL REGISTRATION: ISRCTN78698481. Registered 23 January 2013, retrospectively registered.
Suryanegara et al. (Thu,) conducted a rct in Type 2 diabetes (n=26). High intensity interval training vs. Standard care was evaluated on Cardiac output during prolonged submaximal exercise (L/min) (p=0.05). High intensity interval training significantly reduced cardiac output by 21% during prolonged submaximal exercise in patients with type 2 diabetes compared to standard care.