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Transfer-learning succeeded to extract information from unlabeled sequence databases relevant for various protein prediction tasks. SeqVec modeled the language of life, namely the principles underlying protein sequences better than any features suggested by textbooks and prediction methods. The exception is evolutionary information, however, that information is not available on the level of a single sequence.
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Michael Heinzinger
Ahmed Elnaggar
Yu Wang
SHILAP Revista de lepidopterología
BMC Bioinformatics
Columbia University
Technical University of Munich
Institute for Advanced Study
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Heinzinger et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69da23e7a6045d71bfa3c185 — DOI: https://doi.org/10.1186/s12859-019-3220-8