Incorporating hydrolytic ATP-ADP-Pi dynamics into a Hill-type muscle model successfully predicted the force decay observed during isometric contractions of rabbit skeletal muscle, reducing the fit error by approximately 10%.
Incorporating phosphate kinetics into a Hill-type model accurately predicts short-term skeletal muscle force decay during isometric contractions.
were employed for model verification, with the finding that our suggested model enhancement proved eminently promising. We discuss implications of our model approach for enhancing muscle models in general, as well as a few aspects regarding the significance of phosphate kinetics as one contributor to muscle fatigue.
Rockenfeller et al. (Tue,) conducted a other in Skeletal muscle exhaustion (n=2). Hill-type muscle model incorporating phosphate kinetics vs. Classical Hill-type model without phosphate dynamics was evaluated on Force decay during isometric contractions (model fit to experimental data). Incorporating hydrolytic ATP-ADP-Pi dynamics into a Hill-type muscle model successfully predicted the force decay observed during isometric contractions of rabbit skeletal muscle, reducing the fit error by approximately 10%.