Key points are not available for this paper at this time.
This work aims to evaluate the antioxidant and protective effect of Raphia hookeri (Rh) fruit extracts and powders against aluminum induced neurotoxicity in rats. Extracts and powder were prepared using fruit mesocarp. Phytochemical contents (phenolic content and flavonoïd) and antioxidant in vitro activity were evaluated through the DPPH radical scavenging capacity, the ability to reduce ferric ion and Hydroxyl radical scavenging ability. The neurocognitive dysfunction, the activity of acetylcholinesterase (AChE) and activities of antioxidant in vivo indices were evaluated in the plasma, liver and brain of aluminum chloride (AlCl3) induced neurotoxicity in rats. The highest total phenolic (76.34 mg Eq AG/g of extract), flavonoïds’ contents (13.32 mg Eq CAT/g of extract), the best DPPH scavenging activity and the ability to reduce ferric ion (Fe3+) were obtained with aqueous extract. The administration of aqueous extract (200 and 400 g/kg bw) and powder (5% and 10 %) during 28 days resulted in a significant decrease (P Treatment with aqueous extract and powder of Rh mesocarp ameliorated neurobehavioral changes by enhancing antioxidant activities, cognitive functions. Therefore Rh would protect oxidative damage and preserve neurone functions.
Doungue et al. (Wed,) studied this question.