Total blood volume, left ventricular e' velocity, and left atrial strain were independently associated with pulmonary capillary wedge pressure in chronic heart failure patients (all P < 0.05).
Observational (n=66)
p-value: p=<0.001
AIMS: Elevated cardiac filling pressures producing clinical congestion in heart failure (HF) patients may be secondary to intravascular volume expansion or abnormalities in cardiac diastolic properties. The objective of this study was to assess the extent to which measures of myocardial function and intravascular volume correlate with haemodynamic abnormalities in chronic HF. METHODS AND RESULTS: Subjects underwent invasive haemodynamic assessment, measurement of total blood volume (TBV) using radiolabel indicator-dilution methodology, and echocardiography to evaluate cardiac structure and function. Patients were divided into those with hypervolaemia (defined as TBV > +8% above referenced normal volume) and normal volume ('euvolaemia') (TBV ≤ + 8%). Of 66 patients, 39 (59%) were hypervolaemic and 27 (41%) normal TBV. Central venous pressure (CVP, P = 0.01) and pulmonary capillary wedge pressure (PCWP, P 60%) display elevated filling pressures. Combined analysis of volume, pressure, and cardiac function may be helpful to guide comprehensive assessments of HF status.
Miller et al. (Wed,) conducted a observational in chronic heart failure (n=66). Hypervolaemia (total blood volume > +8%) vs. Euvolaemia (total blood volume ≤ +8%) was evaluated on Central venous pressure and pulmonary capillary wedge pressure (p=<0.001). Total blood volume, left ventricular e' velocity, and left atrial strain were independently associated with pulmonary capillary wedge pressure in chronic heart failure patients (all P < 0.05).