Subclinical depression (HADS-D score >6) was associated with a significantly increased 10-year risk of cardiovascular events in patients with a SCORE risk <5% (OR 2.9; 95% CI 1.1-7.7).
Cohort (n=190)
Does subclinical depression and anxiety increase the risk of cardiovascular events in patients with SCORE <5%?
Subclinical depression and anxiety are associated with an increased risk of cardiovascular events in low- and moderate-risk patients (SCORE <5%).
Effect estimate: OR 2.9 (95% CI 1.1-7.7)
p-value: p=0.0001
Aim. To assess the contribution of anxiety (A) and depression (D) to the increased risk of cardiovascular events (CVEs) in patients with Systematic Coronary Risk Evaluation (SCORE) 6 increased the probability of CVEs — odds ratio (OR) 2,9 (1,1-7,7). In individuals with HADS-D score >6 and/or HADS-A score >7, the probability of CVEs increased — OR 4,9 (1,4-17,9). A combination of impaired two or more parameters of the lipid profile, systolic blood pressure >130 mm Hg and HADS-D score >6 and/or HADS-A score >7 increased the risk of CVE — OR 7,3 (2,48-21,36). Conclusion. Depression, including subclinical depression, is associated with an increased risk of CVEs in patients with a SCORE risk <5%.
Смирнова et al. (Sat,) conducted a cohort in Low- and moderate-risk patients (SCORE <5%) (n=190). Subclinical depression (HADS-D score >6) vs. Absence of subclinical depression was evaluated on Cardiovascular events (death from CVDs, acute MI, unstable angina, stroke, revascularization) (OR 2.9, 95% CI 1.1-7.7, p=0.0001). Subclinical depression (HADS-D score >6) was associated with a significantly increased 10-year risk of cardiovascular events in patients with a SCORE risk <5% (OR 2.9; 95% CI 1.1-7.7).
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