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Abstract Inspired by biology, in which a bimetallic hydroxide‐bridged zinc(II)‐containing enzyme is utilized to catalytically hydrolyze phosphate ester bonds, the utility of a zirconium(IV)‐cluster‐containing metal–organic framework as a catalyst for the methanolysis and hydrolysis of phosphate‐based nerve agent simulants was examined. The combination of the strong Lewis‐acidic Zr IV and bridging hydroxide anions led to ultrafast half‐lives for these solvolysis reactions. This is especially remarkable considering that the actual catalyst loading was a mere 0.045 % as a result of the surface‐only catalysis observed.
Katz et al. (Sun,) studied this question.