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The NBDC for ATTR-CM are highly specific 97% (95% CI 0.91-0.99) in clinical setting, and diagnostic performance was further refined here using new cut-offs for sFLC ratio in patients with CKD. A grade 0 radionuclide scan all but excludes ATTR-CM but occurs in most patients with AL-CA. Grade 1 scans in patients with CA and no MG are strongly suggestive of early ATTR-type, but require urgent histologic corroboration.
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Muhammad U. Rauf
Philip N. Hawkins
Francesco Cappelli
European Heart Journal
University College London
University of Bologna
Istituti di Ricovero e Cura a Carattere Scientifico
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Rauf et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d5768ae1904fea15e911d9 — DOI: https://doi.org/10.1093/eurheartj/ehad139