Does pulsed field ablation prevent atrial tachyarrhythmia and procedural failure compared to conventional thermal ablation in patients with paroxysmal atrial fibrillation?
Patients with paroxysmal atrial fibrillation receiving a catheter-based therapy
Pulsed field ablation
Conventional thermal ablation
Freedom from a composite of initial procedural failure, documented atrial tachyarrhythmia after a 3-month blanking period, antiarrhythmic drug use, cardioversion, or repeat ablation at 1 yearcomposite
Pulsed field ablation is noninferior to conventional thermal ablation for the treatment of paroxysmal atrial fibrillation at 1 year.
Among patients with paroxysmal atrial fibrillation receiving a catheter-based therapy, pulsed field ablation was noninferior to conventional thermal ablation with respect to freedom from a composite of initial procedural failure, documented atrial tachyarrhythmia after a 3-month blanking period, antiarrhythmic drug use, cardioversion, or repeat ablation and with respect to device- and procedure-related serious adverse events at 1 year. (Funded by Farapulse-Boston Scientific; ADVENT ClinicalTrials.gov number, NCT04612244.).
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Vivek Y. Reddy
Edward P. Gerstenfeld
Andrea Natale
New England Journal of Medicine
University of California, San Francisco
Massachusetts General Hospital
Case Western Reserve University
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Reddy et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69d2310aab1f847d95758e3b — DOI: https://doi.org/10.1056/nejmoa2307291