Abstract B077: Spatial patterns of immune cell states are associated with poor response to neoadjuvant chemotherapy in high-grade serous ovarian cancer

Abstract The composition and functional state of the tumor microenvironment (TME) play a crucial role in determining the response to neoadjuvant chemotherapy (NACT) in high-grade serous ovarian cancer (HGSC) patients. Understanding these complex interactions is essential for patient stratification and the development of novel combination therapies. With the advent of spatial transcriptomics technologies, studying the TME in terms of not only quantitative, qualitative, but also spatial aspects have become possible. This study aimed to investigate the spatial distribution and functional states of different cell types within the HGSC TME and their association with NACT response. We utilized 10 publicly available post-NACT HGSC 10x Visium spatial transcriptomics samples comprising patients with good (n=3), partial (n=2), and poor (n=5) responses to NACT. Each spot on Visium hematoxylin and eosin (H 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84 (5 Suppl₂): Abstract nr B077.