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The stiffness of a biological tissue is a great indicator of its health state. Thus, adding quantitative stiffness to medical imaging systems could be a strong aid for diagnosis, notably in cases of small lesions or inaccessible tissues. In our team, we developed noise correlation elastography for full field coherent imaging technics such as digital holography or FFOCT). In the present study, we demonstrate the advantages of this method for the non-invasive quantification of mechanical anisotropy in fibrous biological tissues, both when validating it on finite-difference simulated data, in anisotropic tissue-mimicking polymer fantoms, and ex-vivo and in-vivo biological samples.
Dufour et al. (2024) studied this question.